Some gynecologists, especially those practicing integrative or holistic gynecology, prefer natural progesterone to synthetics when treating women with endometriosis. Why Is Progesterone Preferred to Progestin by Some Physicians? The study authors note that no good research has tracked the difference for heart attack risk or stroke, other problems identified in the WHI. A review of three studies published in Systematic Reviews in July 2016 concluded that natural progesterone “was associated with lower breast cancer risk compared to synthetic progestins” (when taken along with estrogen therapy). Still, smaller studies have found health benefits of natural over synthetic progesterone. In results published in January 2013 in Obstetrics and Gynecology, researchers concluded that long-term use of these hormones in tandem increases cardiovascular, breast cancer, and other risks. The famed Women’s Health Initiative (WHI), for example, followed more than 160,000 women over 15 years (its primary study was for progestin and estrogen treatment together, for women around menopause). What We Know About Natural Progesteroneīut as the article notes, natural progesterone has not been studied in the same large, long-term clinical trials as synthetic hormones have been. Is Natural Progesterone Safer Than Progestin?Īccording to an article published in Harvard Women’s Health Watch, women typically flock to bioidentical hormones because they think they might be safer than synthetic hormones. Compounding pharmacies make progesterone products in capsules, topical creams, and vaginal suppositories. Here, your doctor orders any dosage, and the pharmacy creates the drug in that amount specifically for you. Natural progesterone can also be manufactured in local compounding pharmacies. These include Prometrium (progesterone, USP), in 100 milligram (mg) and 200 mg capsules, and the vaginal gel Crinone. Natural progesterone is available by prescription in several products made by pharmaceutical manufacturers. RELATED: What Are the Best and Worst Birth Control Methods? Products are labeled United States Pharmacopoeia (USP) progesterone, which means they meet standards for product quality. It is altered in the lab to more closely resemble the progesterone in the body. What Is Natural Progesterone?Īlso known as a bioidentical hormone, natural progesterone is a hormone derived from plant fats and oils. And the birth control injection Depo-Provera (medroxyprogesterone) is progestin-only. The intrauterine device Mirena (levonorgestrel) also releases progesterone solo. Pills include Aygestin (norethindrone acetate) or progestin-only birth control pills such as Camila and Nor-QD (norethindrone). ![]() Synthetic progesterones, known as “progestins,” are available in several different forms. Different Forms of Synthetic Progesterone Are Available
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